Laboratory Cell Technologies

Nelli Babayan

Head of the laboratory, PhD
E-mail: n_babayan@mb.sci.am

Laboratory members

Natalya Sargsyan, PhD
Researcher
Ruzanna Grigoryan, PhD
Researcher
Lusine Khondkaryan
Researcher
Gohar Tadevosyan
Junior researcher
Lilit Apresyan
Junior researcher
Alisa Manukayn
Senior laboratory assistant

General information

The research activities of the Cell Technologies laboratory have two directions – basic research (cancer research) and applied research (toxicology). Basic research is related to the study of DNA damage and repair processes in tumor and healthy cells. Applied research is aimed at evaluating the biological activity and safety of potential drugs and natural compounds using standard and/or newly developed by us in vitro and in silico approaches.

Current Research Projects

  • «Application of deep neural network algorithms as a tool for in silico prediction of small molecules metabolism and toxicity», SC RA / 20TTCG-1F004.
  • «Study of anti-inflammatory and antioxidant properties of plant oils for ointments preparation», SC RA / 21-001.

Selected publications

  1. Tevosyan A, Khondkaryan L, Khachatrian H, Tadevosyan G, Apresyan L, Babayan N, Stopper H, Navoyan Z. Improving VAE based molecular representations for compound property prediction. J Cheminform. 2022 Oct 14;14(1):69. doi: 10.1186/s13321-022-00648-x
  2. Babayan N, Grigoryan B, Khondkaryan L, Tadevosyan G, Sarkisyan N, Grigoryan R, Apresyan L, Aroutiounian R, Vorobyeva N, Pustovalova M, Grekhova A, Osipov AN. Laser-Driven Ultrashort Pulsed Electron Beam Radiation at Doses of 0.5 and 1.0 Gy Induces Apoptosis in Human Fibroblasts. Int J Mol Sci. 2019 Oct 17;20(20):5140. doi: 10.3390/ijms20205140
  3. Babayan N, Tadevosyan G, Khondkaryan L, Grigoryan R, Sarkisyan N, Haroutiounian R, Stopper H. Ochratoxin A induces global DNA hypomethylation and oxidative stress in neuronal cells in vitro. Mycotoxin Res. 2020 Feb;36(1):73-81. doi: 10.1007/s12550-019-00370-y
  4. Thooptianrat T, Chaveerach A, Sudmoon R, Tanee T, Liehr T, Babayan N. Screening of phytochemicals and toxicity of medicinal plants, Dillenia species, reveals potential natural product resources. J Food Biochem. 2017;41(3):e12363. doi: 10.1111/jfbc.12363
  5. Harutyunyan T, Hovhannisyan G, Babayan N, Othman MA, Liehr T, Aroutiounian R. Influence of aflatoxin B1 on copy number variants in human leukocytes in vitro. Mol Cytogenet. 2015 Apr 9;8:25. doi: 10.1186/s13039-015-0131-x