Laboratory of Cell Biology and Virology

Professor Zaven Karalyan

Head of the laboratory, DSc


Laboratory members

Elena Karalova, DSc

Leading researcher

Liana Abroyan, PhD


Aida Avetisyan, PhD


Lina Hakobyan, PhD


Hranush Avagyan, PhD


Zara Semerjyan, PhD


Henrik Voskanyan, PhD


Nane Bayramyan, PhD

Junior researcher

Hranush Arzumanyan, PhD

Junior researcher

Sona Hakobyan

Junior researcher

Arpine Poghosyan

Junior researcher

Bagrat Baghdasaryan

Senior laboratory assistant

Hripsik Burjakhyan

Laboratory assistant

General information

The laboratory of Cell Biology and Virology studies fundamental aspects of viral pathogenesis. The aim of our research is to identify the cellular, molecular and genetic mechanisms underlying the pathogenesis of DNA and RNA viruses (African swine fever virus, human coronavirus, honeybee viruses, megaviruses) and virus-host interactions. We also focus on the research of the survival and transmission pathways of viruses, as well as the determination of the biological factors that influence the ecology of viruses (impact of climate change on biological invasions and the ecology of viruses in regional context).

The laboratory develops new strategies for the prevention and treatment of viral diseases. In this regard, a new platform for preclinical studies of antivirial drugs is being designed.

Current Research Projects

  • «Application of computer screening technologies, molecular modeling and biochemical analysis for the development of new potential drugs for the treatment of coronavirus infection», SC RA – SC-RB SCST / 21-SC-RBSCST-1F004
  • «Establishment of an universal platform for preclinical studies of anticoronaviral preparations», SC RA / 21APP-1F007
  • «Application of deep learning, molecular modeling and biomedical assays to develop as a small-like drug compounds as a potential SARS COV-2 main protease inhibitors», ANSO-CR-PP-2021-04

Selected publications

  1. Avagyan H, Hakobyan S, Poghosyan A, Hakobyan L, Abroyan L, Karalova E, Avetisyan A, Sargsyan M, Baghdasaryan B, Bayramyan N, Avetyan D, Karalyan Z. Severe Acute Respiratory Syndrome Coronavirus-2 Delta Variant Study In Vitro and Vivo. Curr Issues Mol Biol. 2022 Dec 30;45(1):249-267. doi: 10.3390/cimb45010019
  2. Ghazaryan A, Adamyan S, Hayrapetyan T, Papov G, Hakobyan L, Abroyan L, Bayramyan N, Hakobyan S, Poghosyan A, Torossian H, Karalyan Z. Comparative staining of Rhinolophus spp. white blood cells in blood smears. Vet World. 2022 Mar;15(3):750-756. doi: 10.14202/vetworld.2022.750-756
  3. Avagyan H, Hakobyan S, Poghosyan A, Bayramyan N, Arzumanyan H, Abroyan L, Avetisyan A, Hakobyan L, Karalova E, Karalyan Z. African Swine Fever Virus Manipulates the Cell Cycle of G0-Infected Cells to Access Cellular Nucleotides. Viruses. 2022 Jul 22;14(8):1593. doi: 10.3390/v14081593
  4. Hakobyan SA, Ross PA, Bayramyan NV, Poghosyan AA, Avetisyan AS, Avagyan HR, Hakobyan LH, Abroyan LO, Harutyunova LJ, Karalyan ZA. Experimental models of ecological niches for African swine fever virus. Veterinary Microbiology. 2022;266:109365. doi: 10.1016/j.vetmic.2022.109365
  5. Avagyan H, Mirzoyan A, Mirzoyan F, Izmailyan R, Hakobyan S, Voskanyan H, Semerjyan Z, Avetisyan A, Arzumanyan H, Karalova E, Abroyan L, Hakobyan L, Bayramyan N, Gevorgyan N, Karalyan A, Karalyan Z. New composition of tungsten has a broad range of antiviral activity. Antivir Chem Chemother. 2022 Jan-Dec;30:20402066221090061. doi: 10.1177/20402066221090061