Laboratory of Cell Biology and Virology
Professor Zaven Karalyan
Head of the laboratory, DSc
E-mail: zkaralyan@yahoo.com
Laboratory members
Elena Karalova, DSc
Leading researcher
Liana Abroyan, PhD
Researcher
Aida Avetisyan, PhD
Researcher
Lina Hakobyan, PhD
Researcher
Hranush Avagyan, PhD
Researcher
Zara Semerjyan, PhD
Researcher
Sona Hakobyan
Researcher
Elina Arakelova, PhD
Researcher
Vahagn Gevorgyan, PhD
Researcher
Henrik Voskanyan, PhD
Researcher
Nane Bayramyan, PhD
Junior researcher
Hranush Arzumanyan, PhD
Junior researcher
Arpine Poghosyan
Junior researcher
Bagrat Baghdasaryan
Senior laboratory assistant
Hripsik Burjakhyan
Laboratory assistant
General information
The laboratory of Cell Biology and Virology studies fundamental aspects of viral pathogenesis. The aim of our research is to identify the cellular, molecular and genetic mechanisms underlying the pathogenesis of DNA and RNA viruses (African swine fever virus, human coronavirus, honeybee viruses, megaviruses) and virus-host interactions. We also focus on the research of the survival and transmission pathways of viruses, as well as the determination of the biological factors that influence the ecology of viruses (impact of climate change on biological invasions and the ecology of viruses in regional context).
The laboratory develops new strategies for the prevention and treatment of viral diseases. In this regard, a new platform for preclinical studies of antivirial drugs is being designed.
Current Research Projects
- «Application of computer screening technologies, molecular modeling and biochemical analysis for the development of new potential drugs for the treatment of coronavirus infection», SC RA – SC-RB SCST / 21-SC-RBSCST-1F004
- «Establishment of an universal platform for preclinical studies of anticoronaviral preparations», SC RA / 21APP-1F007
- «Application of deep learning, molecular modeling and biomedical assays to develop as a small-like drug compounds as a potential SARS COV-2 main protease inhibitors», ANSO-CR-PP-2021-04
Selected publications
- Avagyan H, Hakobyan S, Poghosyan A, Hakobyan L, Abroyan L, Karalova E, Avetisyan A, Sargsyan M, Baghdasaryan B, Bayramyan N, Avetyan D, Karalyan Z. Severe Acute Respiratory Syndrome Coronavirus-2 Delta Variant Study In Vitro and Vivo. Curr Issues Mol Biol. 2022 Dec 30;45(1):249-267. doi: 10.3390/cimb45010019
- Ghazaryan A, Adamyan S, Hayrapetyan T, Papov G, Hakobyan L, Abroyan L, Bayramyan N, Hakobyan S, Poghosyan A, Torossian H, Karalyan Z. Comparative staining of Rhinolophus spp. white blood cells in blood smears. Vet World. 2022 Mar;15(3):750-756. doi: 10.14202/vetworld.2022.750-756
- Avagyan H, Hakobyan S, Poghosyan A, Bayramyan N, Arzumanyan H, Abroyan L, Avetisyan A, Hakobyan L, Karalova E, Karalyan Z. African Swine Fever Virus Manipulates the Cell Cycle of G0-Infected Cells to Access Cellular Nucleotides. Viruses. 2022 Jul 22;14(8):1593. doi: 10.3390/v14081593
- Hakobyan SA, Ross PA, Bayramyan NV, Poghosyan AA, Avetisyan AS, Avagyan HR, Hakobyan LH, Abroyan LO, Harutyunova LJ, Karalyan ZA. Experimental models of ecological niches for African swine fever virus. Veterinary Microbiology. 2022;266:109365. doi: 10.1016/j.vetmic.2022.109365
- Avagyan H, Mirzoyan A, Mirzoyan F, Izmailyan R, Hakobyan S, Voskanyan H, Semerjyan Z, Avetisyan A, Arzumanyan H, Karalova E, Abroyan L, Hakobyan L, Bayramyan N, Gevorgyan N, Karalyan A, Karalyan Z. New composition of tungsten has a broad range of antiviral activity. Antivir Chem Chemother. 2022 Jan-Dec;30:20402066221090061. doi: 10.1177/20402066221090061