Laboratory of Microbial Genomics
Anahit Sedrakyan
Head of the laboratory, PhD
E-mail: a_sedrakyan@mb.sci.am
Laboratory members
Alvard Hovhannisyan, PhD
Researcher
Karine Arakelova
Researcher
Magdalina Zakharyan
Junior researcher
Shoghik Hakobyan
Junior researcher
General information
The research activities of the laboratory are focused on the whole genome-based analyses of molecular epidemiology and thorough understanding of antimicrobial resistance mechanisms of the key bacterial pathogens associated with the spread of difficult-to-treat infections in Armenia. These efforts are aimed at identifying the emergence, prevalence and dynamic of most important antimicrobial resistant pathogens belonging to high-risk epidemic clones that need to be monitored and controlled, as well as identifying other highly virulent isolates that cause complex and hard-to-treat infections.
Current Research Projects
- In-depth characterization of the most common bacterial pathogens displaying clinically important antimicrobial resistance to improve antimicrobial therapy approaches as well as establish their molecular epidemiology and genetic relatedness within national and international context.
- To explore the potential of bacteriophages isolated in the laboratory to control multidrug-resistant bacterial infections and spread of antimicrobial resistance.
Selected publications
- Sedrakyan A, Ktsoyan Z, Arakelova K, Gevorgyan Z, Zakharyan M, Hakobyan S, Hovhannisyan A, Arakelyan A, Aminov R. Molecular Epidemiology and Virulence of Non Typhoidal Salmonella in Armenia. Int J Mol Sci. 2022 Aug 18;23(16):9330. doi: 10.3390/ijms23169330
- Sedrakyan AM, Ktsoyan ZA, Arakelova KA, Zakharyan MK, Hovhannisyan AI, Gevorgyan ZU, Mnatsakanyan AA, Kakabadze EG, Makalatia KB, Chanishvili NA, Pirnay JP, Arakelyan AA, Aminov RI. Extended-Spectrum β Lactamases in Human Isolates of Multidrug-Resistant Non typhoidal Salmonella enterica. Front Microbiol. 2020 Dec 22;11:592223. doi: 10.3389/fmicb.2020.592223
- Ktsoyan Z, Budaghyan L, Agababova M, Mnatsakanyan A, Arakelova K, Gevorgyan Z, Sedrakyan A, Hovhannisyan A, Mkrtchyan M, Zakharyan M, Arakelyan A, Aminov R. Potential Involvement of Salmonella Infection in Autoimmunity. Pathogens. 2019 Jul 3;8(3):96. doi: 10.3390/pathogens8030096
- Ktsoyan ZA, Mkrtchyan MS, Zakharyan MK, Mnatsakanyan AA, Arakelova KA, Gevorgyan ZU, Ktsoyan LA, Sedrakyan AÌ, Hovhannisyan AI, Ghazaryan KA, Boyajyan AS, Aminov RI. Differential induction of total IgE by two Salmonella enterica serotypes. Front Cell Infect Microbiol. 2015 May 26;5:43. doi:10.3389/fcimb.2015.00043
- Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Manukyan GP, Arakelova KA, Hovhannisyan AI, Arakelyan AA, Ghazaryan KA, Zakaryan MK, Aminov RI. Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. Front Cell Infect Microbiol. 2013 Jan 28;3:2. doi: 10.3389/fcimb.2013.00002