Group of Molecular Neurobiology
Vitya Vardanyan
Head of the group, PhD
E-mail: v_vardanyan@mb.sci.am
Group members
Tatevik Karapetyan
Senior laboratory assistant
Liana Mkrtchyan
Senior laboratory assistant
General information
Investigations in our research group are focused on uncovering the molecular mechanisms underlying the gating, selectivity, expression and modulation of ion channels. We also study the pathological mechanisms of events leading to human diseases due to impaired function of channels. The focus of our research is predominantly on K + channels, particularly those of KCNQ and Kv2 family. A large number of human diseases are associated with mutations in these channels that occur both inheritably or spontaneously. We investigate biophysical, biochemical and structural properties of corresponding mutants in vitro utilizing a broad spectrum of molecular biological, biochemical, electrophysiological and imaging techniques. Our long term projects are:
- modulation mechanism of KCNQ1 channels by external K + ;
- investigation of the pathological mechanisms underlying the developmental and epileptic encephalopathies associated with KCNB1 gene mutations;
- functional role of the Zn 2+ -binding domain of Kv2 channels.
Current Research Projects
- «Practical training in molecular and cellular biology to advance education and research at two strategic universities in Armenia», VW Foundation / AZ9A908
Selected publications
1. Schütter N, Barreto YC, Vardanyan V, Hornig S, Hyslop S, Marangoni S, Rodrigues-Simioni L, Pongs O, Dal Belo CA. Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom. Toxins (Basel). 2019 Jun 12;11(6):335. doi:10.3390/toxins11060335
2. Vardanyan V, Pongs O. Coupling of voltage-sensors to the channel pore: a comparative view. Front Pharmacol. 2012 Jul 27;3:145. doi: 10.3389/fphar.2012.00145
3. Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nat Neurosci. 2011 Nov 20;15(1):138-45. doi: 10.1038/nn.2985
4. Ma LJ, Ohmert I, Vardanyan V. Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis. Biophys J. 2011 Feb 16;100(4):885-94. doi: 10.1016/j.bpj.2010.12.3726
5. Ader C, Schneider R, Hornig S, Velisetty P, Vardanyan V, Giller K, Ohmert I, Becker S, Pongs O, Baldus M. Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity. EMBO J. 2009 Sep 16;28(18):2825-34. doi: 10.1038/emboj.2009.218